Wednesday, December 16, 2009

PROTOKINETIX, INC Stock Symbol :: PKTX

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PROTOKINETIX, INC
Stock Symbol :: PKTX
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PROTOKINETIX, INC (PKTX) ProtoKinetix, Inc. is a biotechnology company that has developed and patented a family of synthetic anti-aging glycopeptides AAGP™ for medicine and the biotechnology and cosmetic industries.
Recent Price$.081
Market Capitalization$4.45M
Est FloatN/A
Outstanding Shares55M
QuotationOTC.BB

ProtoKinetix, Inc.

2225 Folkestone Way
West Vancouver, BC
V7S 2Y6


Phone: 604-926-6627
Fax: 604-926-6632
http://www.protokinetix.com
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Current Projects

L'Oreal Independently Validates ProtoKinetix' AAGP™ Cosmetic

ProtoKinetix recently announced that L’Oreal (LOR) has applied for a patent using the ProtoKinetix’ Anti-Aging Glyco Peptide (AAGP™) family of molecules as the basis for a skin lightening agent. This application had already been identified by PKTX as one of the many cosmetic applications included in its patents. If L’Oreal’s patent application were to be successful, they would have to negotiate a license agreement with PKTX to commercialize the use of AAGP™ in any product. This patent application by L’Oreal strongly supports the tremendous potential of AAGPs.

ProtoKinetix’ Advisory Boards Launch Major Commericial Initiatives for It's AAGPs

ProtoKinetix’ Business Advisory Board Chairman, Dr. Edward Martin, recently reported on progress implemented by the Corporate Advisory Boards. In addition to the several major corporations currently evaluating AAGP™, the Advisory Boards have been able to successfully present the ProtoKinetix family of anti-agingglycopeptides to several senior pharmaceutical executives. These initiatives are predominantly structured to build partnering/ licensing relationships using AAGP™ in medical therapies and regenerative medicine.



Company Overview
ProtoKinetix, Inc. (OTCBB: PKTX)

ProtoKinetix is a biotech company focused on developing and licensing patented anti-aging glycopeptides (AAGP™) to the health care, biotechnology and skin care/cosmetic industries. Since 2005, ProtoKinetix has been engaged in groundbreaking scientific research. Several recent tests and trials on ProtoKinetix’ AAGP™ cryopreservation (freezing cells to -196°C) has shown promising results across multiple cell lines. AAGP™ molecules have demonstrated to enhance the health and extend the life of cells and seem to carry anti-inflammatory properties. ProtoKinetix is the first company to make a stable and non-toxic version.

With a versatile biotechnology platform in place, ProtoKinetix has entered into discussions with a number small and large, Fortune 500 companies to bring life-enhancing AAGP™ containing products to market. In September 2008, ProtoKinetix announced its first commercial contract to manufacture AAGP™ as the primary active ingredient in an anti-inflammatory sports cream in the US. This contract is one of several in the pipeline that is positioning ProtoKinetix on a path of rapid revenue growth and commercial success.

Patented Technology

AAGP™s were invented by ProtoKinetix Director of Science Dr. Geraldine Castelot-Deliencourt, and was developed and protected by patents in partnership with the Institute for Scientific Application of France. For her work in this area, Dr. Castelot-Deliencourt was honored in 2006 with France’shighest award for scientific accomplishment – the Francinov Award.

Dr. Castelot-Deliencourt achieved what was previously thought to be the impossible. She created a stable, non-toxic and synthetic version of AFGP (Anti-Freeze Glycoprotein), a compound naturally produced by some fish, insects, reptiles, bacteria and plants that enable cell survival in freezing

temperatures. The substances that prevent these organisms from freezing were isolated, characterized and designated as antifreeze glycoproteins or AFGPs.

The overall effect of the lab-created version of AFGP, trademarked by ProtoKinetix as AAGP™, is to protect, preserve and in some cases to repair living cells. ProtoKinetix is a pioneer in the clinical testing of AAGP™ in North America and Europe. Under the direction of Dr. Castelot-Deliencourt,

AAGP™ has shown anti-inflammatory effects and appears to improve the health and extend the lifespan of cells.

TF Chem, a state-of-the-art lab headed by Dr. Castelot-Deliencourt in France, successfully developed a prototype derivative of AAGP™. This derivative extends ProtoKinetix’ intelletual property by significantly enhancing the already powerful preservative characteristics of AAGP™. This new

structure has the potential to increase AAGP™ bioactivity by a factor of over one hundred times, enabling AAGP™ to be applied at lower concentrations in each application. These low levels of concentration will be of vital importance across allsegments of pharmaceutical, cell therapy, blood preservation and skin care industries. Minimal concentration requirements of AAGP™ will also enable ProtoKinetix to enter into new therapeutic applications.

Commercial Applications

The extent of the value of the ProtoKinetix family of AAGPs™ is being investigated by companies and ProtoKinetix is targeting commercial entities specializing in regenerative medicine, cellular and tissue therapies, organ transplantation, trauma, blood product banking, anti- inflammation and cosmetics/skin care.

Skincare and Cosmetics

In an article on September 22, 2008, Euromonitor International analyst Virgina Lee pointed out five trends driving the overall growth of the global skin care market: an aging population; increased wealth in emerging markets like China, India and Latin America; pursuit of agelessness;

technological advances; and massive awareness of health & wellness.

These trends are creating a robust world skin care market, which posted sales of $65.7 billion in 2007, up 40% from 2002 and up 7% from 2006. Facial care, nourishers/anti-agers are growing the fastest, with sales of $14.9 billion in 2007, up 67% from 2002. Increased demand from aging baby boomers,

combined with strong market acceptance of Botox, Retinol and other biochemical-based ingredients, bodes well for ProtoKinetix planned entry into highly targeted, global skin care and cosmetics markets.

AAGP™ is an ideal active ingredient for anti-inflammatory and anti-aging skin care lotions. When AAGP™ is combined with Coenzyme Q10, a powerful anti-oxidant effect is achieved that protects and also helps the cells repair previously existing damage. In vitro laboratory tests have shown the AAGP™ molecules can protect in vitro skin cells from damage and prevent the death of cells that would otherwise occur from UV rays and free radicals. AAGP™ appears to protect in vitro skin cells from cold temperatures, oxidation, UV irradiation and pH variations.

Health Care

Health Care Applications of AAGP™ fall into two main categories: (1) harvesting, storage and transplanting cells, tissues and organs; and (2) treatments for conditions and disease caused by stress factors, including UV radiation, oxidation and inflammation. Inflammation and oxidation are both well-known causes of life-threatening conditions and diseases, as well as accelerated aging. In addition, many acute medical problems are benefiting from cell therapies and transplantation of cell, tissues and organs.

AAGP™ is now being used or investigated as a possible solution by many healthcare companies that specialize in medical cell therapies, organ transplant, trauma, blood product banking and anti-inflammation.

ProtoKinetix expects to license several commercial applications from its AAGP™ family as well as expand its ongoing R&D with institutions and businesses. ProtoKinetix is actively in talks with several healthcare companies that are testing the molecule in their specific niche applications.

Stem Cell Research

Stem cell research often precludes advancements in health care, and is considered one of most promising areas of R&D in biotechnology today. According to Research and Markets, the value of stem cell-therapy is projected to increase from $26.6 billion in 2005 to $56.2 billion in 2010 and $96.3

billion in 2015. Medical scientists believe that stem cells offer the potential to cure or mitigate a host of pervasive and debilitating diseases and conditions such as multiple sclerosis, Parkinson’s Alzheimer’s, and diabetes. They also believe that stem cells can be used to repair damaged tissuesor cells caused by caused by injuries to organs, limbs, and the spinal cord.

A top tier company in the Umbilical Cord Blood Preservation (UCB) industry has conducted preliminary tests using AAGP™ as a protective agent in the cryofreezing and subsequent thawing of cord blood units. Post-thawing, those that had used a small concentration of AAGP™ showed a 104% average increase in yield compared to cells without AAGP™, and a function level 38% greater than the control group.

UCB companies enable families to save their newborn’s cord blood for possible future medical use in the treatment of over 40-diseases, including blood cancers and genetic disease. Since a major loss of cells occurs in the transportation and storage of the cord blood prior to freezing, it has been suggested that AAGP™ be added to the cord blood bags before shipping. This could further assist in the increase of the viable cell population. In laboratory controlled tests, AAGP™-treated cells have survived harsh environmental stresses such as cryopreservation hydrogen peroxide oxidation, inflammation from interleukin 1Beta, UV-C radiation, and nutrient deprivation.

Leadership

Ross L. Senior, LLB, President and CEO

In 2005, Mr. Senior co-founded Rowan All Natural Skin Care, Inc., a Canadian-based provider of skin care products for the health care profession. In 1988, Mr. Senior founded Ross L. Senior and Associates, a business and technology consulting firm, where he remained its principal from 1988 to 2005. He practiced law from 1974 to 1988 and appeared as a trial lawyer in various tribunals until 2005.


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